Research record
Overview
Compound name: ARA-290
Alternative name: Cibinetide
Compound classification: Synthetic erythropoietin-derived peptide
Brief factual description:
ARA-290 (Cibinetide) is an 11–amino acid synthetic peptide derived from the tissue-protective domain of erythropoietin (EPO). It selectively activates the EPOR/CD131 heteroreceptor complex involved in anti-inflammatory and cytoprotective signaling, while avoiding stimulation of erythropoiesis.
Mechanism of Action
Primary biological targets: EPOR/CD131 heteroreceptor complex
Affected systems: Nervous, immune, metabolic
Core mechanisms:
Activation of tissue-protective EPO receptor pathway
No activation of erythropoietic EPOR homodimers
Downstream effects:
Suppression of pro-inflammatory cytokines
Reduction of oxidative stress
Promotion of nerve repair and cellular survival pathways




