Research record
Overview
Compound name: Growth Hormone–Releasing Peptide-2
Common abbreviation: GHRP-2
Compound classification: Synthetic peptide; growth hormone secretagogue
Brief factual description:
GHRP-2 is a synthetic peptide that stimulates endogenous growth hormone (GH) release by activating the growth hormone secretagogue (ghrelin) receptor. It is known for producing strong, rapid GH pulses and exhibits greater potency than earlier GHRPs, while still influencing appetite- and cortisol-related pathways.
Mechanism of Action
Primary biological targets: Growth hormone secretagogue receptor (GHS-R1a)
Affected systems: Endocrine, metabolic
Receptor selectivity:
High affinity for ghrelin receptor; distinct from GHRH receptor pathways
Downstream signaling effects:
Rapid stimulation of pulsatile GH release
Synergistic GH release when combined with GHRH analogs
Secondary activation of appetite and stress-related signaling




