Research record
Overview
Compound name: Human Menopausal Gonadotropin
Common abbreviations: hMG; Menotropins
Compound classification: Gonadotropin hormone preparation
Brief factual description:
Human menopausal gonadotropin (hMG) is a hormone preparation derived from the urine of postmenopausal women or produced via purified processes, containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. It is used to stimulate ovarian follicle development in women and spermatogenesis in men.
Mechanism of Action
Primary biological targets:
FSH receptor (FSHR)
Luteinizing hormone/chorionic gonadotropin receptor (LHCGR)
Affected systems: Reproductive, endocrine
Receptor selectivity:
Dual activity via FSH and LH receptors
Downstream signaling effects:
FSH: follicular growth, Sertoli cell stimulation, spermatogenesis
LH: steroidogenesis, ovulation, testosterone synthesis




