Research record
Overview
Compound name: Kisspeptin-10
Alternative names: KP-10; KISS1-10
Compound classification: Synthetic peptide; neuroendocrine signaling peptide
Brief factual description:
Kisspeptin-10 is a short, biologically active fragment of the KISS1 gene–encoded peptide family. It is a potent regulator of reproductive hormone release, acting as a key upstream trigger for gonadotropin-releasing hormone (GnRH) secretion and subsequent activation of the hypothalamic–pituitary–gonadal (HPG) axis.
Mechanism of Action
Primary biological targets: Kisspeptin receptor (KISS1R / GPR54)
Affected systems: Neuroendocrine, reproductive
Receptor selectivity:
High specificity for KISS1R
Downstream signaling effects:
Activation of phospholipase C (PLC)
Increased intracellular calcium signaling
Stimulation of GnRH neuron firing and secretion
Subsequent release of LH and FSH from the pituitary
