Research record
Overview
Compound name: MOTS-C
Compound classification: Mitochondrial-derived regulatory peptide
Brief factual description:
MOTS-C is a 16–amino acid peptide encoded within mitochondrial DNA that functions as a systemic metabolic regulator. It plays a role in glucose utilization, insulin sensitivity, and cellular stress adaptation, acting as a signaling molecule between mitochondria and the nucleus.
Mechanism of Action
Primary biological targets: AMPK pathway; nuclear stress-response genes
Affected systems: Metabolic, mitochondrial, endocrine
Receptor selectivity:
Does not rely on classical surface receptors; enters cells and translocates to the nucleus under metabolic stress
Downstream signaling effects:
Activation of AMP-activated protein kinase (AMPK)
Regulation of glucose uptake
Modulation of nuclear gene expression related to metabolism and stress resilience
