Research record
Overview
Compound name: Adipotide
Alternative name: FTPP (Fat-Targeted Proapoptotic Peptide)
Compound classification: Synthetic peptidomimetic; targeted proapoptotic agent
Brief factual description:
Adipotide is an experimental peptidomimetic compound engineered to selectively target the vasculature of white adipose tissue. It induces apoptosis in adipose-associated endothelial cells, leading to reduction of fat mass through vascular disruption rather than systemic metabolic modulation.
Mechanism of Action
Primary biological targets:
Prohibitin expressed on adipose tissue endothelial cells
Affected systems: Adipose tissue vasculature, metabolic system
Receptor selectivity:
High selectivity for adipose-associated endothelial markers
Downstream signaling effects:
Mitochondrial disruption in targeted endothelial cells
Induction of apoptosis
Collapse of adipose tissue blood supply leading to fat mass reduction
