Research record
Overview
Compound name: Insulin-Like Growth Factor-1 LR3
Common abbreviation: IGF-1 LR3 (Long R3 IGF-1)
Compound classification: Synthetic peptide; insulin-like growth factor analog
Brief factual description:
IGF-1 LR3 is a synthetic analog of human insulin-like growth factor-1 engineered to increase biological potency and extend half-life. Structural modifications reduce binding to IGF binding proteins (IGFBPs), resulting in prolonged receptor activation compared to native IGF-1.
Mechanism of Action
Primary biological targets: IGF-1 receptor (IGF-1R)
Affected systems: Musculoskeletal, metabolic, cellular growth pathways
Receptor selectivity:
High affinity for IGF-1R with partial insulin receptor cross-reactivity
Downstream signaling effects:
Activation of PI3K–Akt–mTOR pathway
Stimulation of MAPK signaling
Increased protein synthesis and cellular proliferation
