Research record
Overview
Compound name: Sermorelin
Alternative names: Sermorelin acetate
Compound classification: Synthetic peptide; growth hormone–releasing hormone (GHRH) analog
Brief factual description:
Sermorelin is a synthetic peptide analog corresponding to the first 29 amino acids of endogenous human growth hormone–releasing hormone (GHRH 1–29). It is used to stimulate the pituitary gland to increase pulsatile secretion of endogenous growth hormone (GH).
Mechanism of Action
Primary biological targets: Growth hormone–releasing hormone receptor (GHRH-R) on pituitary somatotrophs
Affected systems: Endocrine, pituitary axis
Receptor selectivity:
High specificity for the GHRH receptor
Downstream signaling effects:
Activation of adenylate cyclase
Increased intracellular cAMP
Stimulation of pulsatile GH secretion
Indirect elevation of IGF-1 via GH signaling




