Research record
Overview
Compound name: Retatrutide
Development code: LY3437943
Compound classification: Synthetic peptide; triple hormone receptor agonist
Brief factual description:
Retatrutide is an investigational synthetic peptide designed to act as a triple agonist at the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. It is being studied primarily for obesity and metabolic disease due to its combined effects on appetite regulation, energy expenditure, and glucose metabolism.
Mechanism of Action
Primary biological targets:
GLP-1 receptor (GLP-1R)
GIP receptor (GIPR)
Glucagon receptor (GCGR)
Affected systems: Endocrine, metabolic, gastrointestinal, central appetite regulation
Receptor selectivity:
Balanced agonism across three receptors
Downstream signaling effects:
Reduced appetite and caloric intake (GLP-1, GIP)
Increased energy expenditure and fat oxidation (glucagon)
Improved glucose control via insulinotropic effects
